Therapeutic Apheresis

Therapeutic apheresis is a method for removing substances from blood.

Kaneka is market leader for LDL apheresis. Treatements are meant for patients with familiar hypercholesterolemia (FH) and they are aimed towards LDL, HDL and triglycerides, reducing the need for pharmacological therapy.

Kaneka offers a double solution, the first with an adsorbent column LA -15 and the second with a column DL-50, 75 or 100. Both these cartridges are made of cellulose beads, to which dextran sulfate endings are connected that adsorbs LDL, HDL and triglycerides via electro-negativity, preserving every other substance present in the blood.

The blood goes through a filter plasma that separates plasma and the blood cells. The plasma then goes internally in the column LA -15, in which LDL, HDL and triglycerides are absorbed and thus removed from it. The plasma then is reconnected with the blood cells to reenter the patient. Each treatment uses two LA -15, and, thanks to a complex system of 8 pincers and sensors, when a cartridge is full, the plasma moves in the next one, so that it can be regenerated, and vice-versa, making this treatment virtually infinite.

The whole blood gets directly in the cartridge DL -50, DL -75 or DL -100 – according to the volume under treatment – in which it gets treated, and later it is returned clean to the patient.
For both these treatments the suggested frequency is one treatment every one or two weeks, for a treated volume of 3500 ml of plasma for LA 15 and 7000 ml of blood for DL 75.
There are two types of machines designed for these treatments:
MA03 that can support both the treatments.
And DX21 that can only support treatment of whole blood.